Plain-English translation of NCT05141513 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Pancreatic Cancer research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a new approach to treating pancreatic cancer by combining three types of treatment: chemotherapy, radiation therapy before surgery, and then a special kind of radiation (called intraoperative radiation therapy) delivered directly into the surgical area during the operation itself. The goal is to kill any remaining cancer cells in hard-to-reach areas around the pancreas and see if this combined approach is safe for patients.
Pancreatic cancer is difficult to treat because cancer cells often hide in areas around the pancreas that are close to vital organs and blood vessels, making them hard to reach with standard radiation. Research suggests that adding radiation directly during surgery might help control the cancer better in these tricky spots, and doctors want to test whether this is safe to do.
You likely qualify if…
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If you're accepted into the study, you will first receive chemotherapy and radiation therapy as standard cancer treatment. Then you will have surgery to remove the tumor, and during that surgery, the research doctors will deliver an additional focused radiation dose to the area around the pancreas where cancer cells are most likely to remain. After surgery, you'll have follow-up visits to check your health and safety, with the main safety assessment happening about 3 months after your operation.
AI-generated summary from trial data · Jul 12, 2026 · Not medical advice
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