Recruiting

Testing cannabis-based treatments for sleep and pain in multiple sclerosis

Plain-English translation of NCT05269628 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated June 2026 · How we translate trials

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Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This study is testing whether , , or a combination of both can help relieve pain and improve sleep in people with multiple sclerosis. Researchers know that both of these compounds come from cannabis, but they want to understand exactly how—and whether—they actually work to ease pain and sleep problems. Right now, there's not much scientific evidence on this, so this research could help doctors offer better treatment options.

Many people with multiple sclerosis experience chronic pain and sleep problems that significantly affect their quality of life, but current treatments don't work well enough for everyone. This study exists to understand whether this medication could fill that gap and help ease these symptoms.

Do you qualify?

You likely qualify if…

you have been diagnosed with multiple sclerosis (and if you take disease-modifying MS medications, you've been on a stable dose for at least 3 months)
you have had moderate to severe pain for at least 3 months
you are willing to keep taking the same pain medications you currently use throughout the study
you have had recent blood tests (liver function tests within the last 90 days) showing your liver is healthy enough
you are not currently using any cannabis or cannabinoid products and are willing to avoid them for the entire study period

You likely don't qualify if…

you have had an MS relapse in the last 30 days
you have been diagnosed with narcolepsy or have untreated shift work sleep disorder
you are currently pregnant, breastfeeding, or unwilling to use contraception during the study
you have a history of serious mental health conditions including schizophrenia, bipolar disorder, or recent suicidal thoughts with a plan
you have serious heart or liver disease, or a history of seizure disorders

What participation looks like

If you join this study, you will take either CBD, THC, or placebo (a pill with no active ingredient) twice daily for several weeks. You'll start with a lower dose for the first week, then move to the full dose for the rest of the study. During the trial, you'll complete questionnaires and sleep surveys to help researchers understand how the medication affects your pain and sleep. The study lasts approximately 5–6 weeks from start to finish, including follow-up phone calls.

AI-generated summary from trial data · Jun 19, 2026 · Not medical advice

Trial locations(1 site)

United States

University of Michigan, Ann Arbor, Michigan