Plain-English translation of NCT05350475 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Prostate Cancer research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether proton therapy causes fewer side effects than traditional photon therapy in men with advanced prostate cancer who need radiation to both the prostate gland and nearby lymph nodes. Proton therapy is a newer form of radiation that may spare the bladder, rectum, and bowel better than standard photon radiation. The study will compare how many bowel problems men experience with each type of radiation over two years.
Many men with advanced prostate cancer experience lasting bowel problems after radiation therapy. This trial exists to find out whether the newer proton therapy technique can reduce these side effects while treating the cancer just as well as traditional photon radiation.
You will be randomly assigned to receive either proton therapy or photon therapy. Both groups will receive radiation to the prostate and lymph nodes at a dose of 78 Gray given over 39 sessions, five days a week (about 8 weeks total). You will also take hormone therapy (androgen deprivation therapy) for three years, starting three months before radiation begins. You'll have follow-up appointments to check for side effects and quality of life, with the main assessment at 24 months and continued monitoring for up to 10 years after treatment.
AI-generated summary from trial data · Aug 18, 2026 · Not medical advice
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