Plain-English translation of NCT05350475 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Prostate Cancer research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether proton therapy, a newer and more precise form of radiation treatment, causes fewer side effects than standard radiation therapy in men with advanced prostate cancer. Both groups will also receive hormone-blocking medication (androgen deprivation therapy) for three years. The study wants to see if proton therapy's ability to spare nearby healthy organs like the bladder and bowel makes a real difference in how patients feel and function after treatment.
Most men treated with radiation for prostate cancer experience side effects on their bowel and digestive system that can last for years. Proton therapy may spare these healthy organs better than standard radiation, but researchers need to compare the two treatments head-to-head in a large, rigorous trial to prove it actually makes a difference for patients.
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You would be randomly assigned to receive either proton therapy or standard radiation therapy. Before your radiation starts, you'll begin taking hormone-blocking medication for three months, then continue it throughout your 7.5 weeks of radiation (five days a week, 39 treatments total) and for two more years after that. You'll have follow-up appointments to check on side effects and quality of life at regular intervals for up to 10 years after treatment ends.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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