Genetic Testing and MRI to Guide Prostate Cancer Monitoring Choices

This study is testing whether two tools—a genetic test called Genomic Prostate Score and an MRI scan of the prostate—can help men with early-stage prostate cancer make better decisions about their treatment. The trial focuses especially on Black men and men with limited financial resources, who historically have less access to a monitoring approach called active surveillance that lets patients avoid or delay the side effects of surgery or radiation.

Many men with early-stage prostate cancer are over-treated with surgery or radiation when they could safely be monitored instead. This trial wants to make monitoring a safer and more acceptable option by using genetic and imaging tools to identify which men truly need immediate treatment and which ones can be watched carefully.