Plain-English translation of NCT05450822 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Epilepsy research guide →The BrainDrugs-Epilepsy Study is testing whether personalized medicine can improve treatment for people with epilepsy. Researchers will follow patients as they start treatment with lamotrigine or , collecting brain imaging scans, blood and stool samples, and regular symptom updates. The goal is to understand which treatment works best for different people based on their individual brain characteristics and biology.
Many people with epilepsy don't respond well to their first medication, leading to unnecessary delays in finding effective treatment. This study aims to identify biological markers that can predict which medication will work best for each person, potentially helping doctors choose the right treatment faster.
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You'll have an initial visit with comprehensive testing including brain scans (MRI and possibly PET), blood and stool samples, and questionnaires about your mood and quality of life. Then you'll start one of the two seizure medications and use a mobile app daily to log your medication use and track seizure frequency and side effects. You'll have follow-up visits every three months at the clinic or by video/phone consultation, and complete monthly questionnaires through the app to monitor how the medication is working and how you're feeling overall.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
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