Plain-English translation of NCT05450978 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Epilepsy research guide →This research study is looking at how three seizure medications—, , and —behave in a woman's body during pregnancy and after delivery. Researchers want to create a computer model that can predict exactly how much of the medication is in your blood at different stages, so doctors can adjust your dose without needing frequent lab visits. This helps protect you from seizures while keeping your baby as safe as possible.
Pregnancy changes how the body processes seizure medications, which can make them less effective and increase seizure risk. Right now, doctors don't have a reliable way to predict these changes for individual patients, so this treatment often requires many hospital visits for blood tests. This study aims to create a personalized prediction tool that helps doctors manage your medication safely throughout pregnancy and breastfeeding.
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You would be part of this study from before pregnancy (or early in your first trimester) through several months after delivery. During this time, you'll keep a daily diary tracking your seizures, medications, and any side effects, and complete questionnaires about how you're feeling. You'll have blood tests at different stages to measure medication levels in your body, and researchers will use this information to build a personalized model for your care.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
United States
Sponsor
University of Pittsburgh
Collaborators
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Enrollment target
~60 participants
Started
July 2022
Primary completion
April 2027
Age range
18 Years – 45 Years
Sex
Female only
Last updated on clinicaltrials.gov in May 2026.
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Central contact
Tonge Ebai, PhD
The University of Pittsburgh
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