Plain-English translation of NCT05454488 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Prostate Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing a procedure called cryotherapy—a treatment that uses special freezing needles to destroy cancer in the prostate. Researchers want to see how well this focused, targeted approach works for men with intermediate-risk prostate cancer, and whether it helps preserve quality of life compared to other treatment options. The trial will track how many cancers come back, how participants feel afterward, and whether the treatment needs to be repeated.
Standard prostate cancer treatments can affect a man's quality of life, sometimes causing problems with urinary function and sexual health. This trial exists to see if freezing only the cancer itself—rather than treating the entire prostate—can be just as effective while reducing side effects and helping men maintain their everyday health and function.
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If you join this trial, you will receive the freezing treatment (cryotherapy) performed by a surgeon at M.D. Anderson Cancer Center. You will then return for regular follow-up visits and imaging scans at 6 months and beyond to check if the cancer has returned and to monitor how you're doing. You'll also complete questionnaires about your quality of life, urinary symptoms, and sexual function, and researchers will track your PSA blood test results and any side effects for up to 5 years.
AI-generated summary from trial data · Jul 3, 2026 · Not medical advice
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