Plain-English translation of NCT05500963 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Multiple Sclerosis research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether transcutaneous electrical nerve stimulation (TENS)—a non-invasive treatment that uses small electrical pulses delivered through electrodes on your skin—can help reduce fatigue in people with multiple sclerosis. Fatigue is one of the most bothersome symptoms for many MS patients, and this treatment aims to help improve your energy and ability to do daily activities. You would receive either the active treatment or a placebo (sham treatment) over 6 weeks to see if the real treatment makes a difference.
Fatigue is a major problem for people with MS and can make it hard to work, exercise, and enjoy life. Current treatments don't always help enough, so researchers are testing whether this electrical stimulation approach might offer a new way to reduce tiredness and improve how much work your muscles can handle.
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You would visit the University of Colorado Boulder campus 3 times a week for 6 weeks (18 visits total). At each visit, small electrodes would be placed on your legs, and you would receive either the active electrical stimulation or a sham (placebo) version while doing light exercises. The research team would check in on how tired you feel before the treatment starts, at week 4, and again after the 6-week treatment ends. The whole process takes about 6 to 11 weeks from start to finish.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States
Sponsor
University of Colorado, Boulder
Enrollment target
~60 participants
Started
April 2023
Primary completion
May 2027
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in December 2024.
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Central contact
Roger Enoka, PhD
University of Colorado, Boulder
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.