Plain-English translation of NCT05515978 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Prostate Cancer research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Researchers want to know if —a medication commonly used to treat diabetes and prediabetes—can help men with prostate cancer live longer and healthier lives. Some earlier studies suggest this medication might improve outcomes for prostate cancer patients, but this trial will be the first to carefully test it in a controlled, long-term way. You would either receive plus lifestyle guidance, or lifestyle guidance alone, and be followed for up to 10 years.
While past studies hinted that this medication may help prostate cancer patients survive longer and reduce cancer-related deaths, no one has yet tested this idea prospectively in a rigorous clinical trial. This study aims to fill that gap and give doctors solid evidence about whether this treatment truly works.
You likely qualify if…
You likely don't qualify if…
If you join, you'll be randomly assigned to one of two groups: one receiving the medication plus quarterly lifestyle advice through your patient portal, or one receiving lifestyle advice alone. You'll need to have a way to get the medication from your regular pharmacy (billed to your insurance or paid out-of-pocket), and you'll be checked in regularly over up to 10 years to see how you're doing. The study uses your existing medical records and patient portal, so much of the follow-up happens electronically rather than requiring frequent in-person visits.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
United States