Plain-English translation of NCT05590624 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Prostate Cancer research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
The DINE Study is testing whether Mediterranean-type diets—diets rich in vegetables, olive oil, fish, and whole grains—can influence how the body and prostate cancer tissue function in men who have been newly diagnosed with prostate cancer but are choosing to monitor it rather than treat it immediately. Researchers want to understand how these diets affect your metabolism, immune system, gut bacteria, and the prostate tissue itself. This knowledge could help guide dietary recommendations for men managing prostate cancer.
Doctors know that diet can affect cancer risk and progression, but very little research has specifically examined how Mediterranean diets might influence prostate cancer at a metabolic level. This study aims to fill that gap by measuring detailed changes in body chemistry and prostate tissue when men follow these heart-healthy eating patterns.
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You will be randomly assigned to start with either a low-fat or lower-carbohydrate Mediterranean diet two weeks before your initial prostate biopsy. If that biopsy confirms cancer and you are a candidate for active surveillance, you will switch to the other type of Mediterranean diet for another two weeks before a second biopsy. Throughout the study, the research team will provide your meals, monitor your blood work and gut bacteria, and track how well you stick to the diet. You will have follow-up visits approximately 3 months after each dietary phase ends.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
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