Plain-English translation of NCT05594017 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Epilepsy research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Researchers want to understand how scopolamine, a medication that affects brain chemistry, changes the way your brain processes and stores memories. You would receive either scopolamine or a saline placebo (salt water) while undergoing standard brain monitoring for epilepsy surgery, then complete memory tasks to see how the medication affects your performance. This is basic science research aimed at understanding how brain activity supports memory.
Scientists know that certain medications can affect memory and how the brain creates new memories, but they don't fully understand exactly how this happens at the level of brain cell activity. By studying this medication in patients who already have brain electrodes in place for epilepsy treatment, researchers hope to learn more about how brain waves and brain timing relate to memory — knowledge that could eventually help treat memory problems.
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Your participation happens only while you are in the epilepsy monitoring unit with brain electrodes already in place for your clinical care. On day one, you'll receive either the medication or a saline placebo through an IV, then 15 minutes later complete a memory task (like remembering a list of words or a location). The next day or later, you'll receive whichever treatment you didn't get the first day and complete another memory task. You can skip any memory testing session you want, and the study ends when your monitoring electrodes are removed as part of your regular epilepsy treatment.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
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