Recruiting

Five-Session Radiation Therapy for High-Risk Prostate Cancer

Plain-English translation of NCT05613023 on ClinicalTrials.gov ↗ · Source last updated September 2024 · Translation generated June 2026 · How we translate trials

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Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This trial is testing a newer type of radiation therapy called stereotactic body radiotherapy (SBRT) for men with high-risk prostate cancer. The treatment delivers a potentially curative dose of radiation in only 5 visits spread over two weeks. Half of the participants will receive radiation to the prostate alone, while the other half will receive radiation to both the prostate and the lymph nodes in the pelvis to see which approach works better.

Doctors want to find out if giving radiation to the lymph nodes in addition to the prostate can prevent cancer from coming back, and whether this focused treatment approach is safe and effective for patients with aggressive prostate cancer.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have been diagnosed with high-risk prostate cancer that has not spread beyond the prostate gland
you have had recent imaging (MRI and scans) to confirm the cancer has not spread to other parts of your body
you are planned to receive hormone therapy for 12 to 36 months as part of your treatment
you are able to give written consent and are in generally good health

You likely don't qualify if…

you have cancer that has already spread to lymph nodes or other parts of your body
you have had previous radiation therapy to the pelvis
you have inflammatory bowel disease or severe urinary symptoms that would make this treatment unsafe
you have had chemotherapy within the last 6 weeks
you have certain hip replacements or metal implants that would interfere with treatment planning

What participation looks like

If you join this trial, you will receive five radiation treatments on alternate days over about two weeks at an NHS radiotherapy center. The actual radiation sessions are brief, but you may need to come in for planning scans and appointments beforehand. After your treatment finishes, the research team will follow you for at least three and a half years with regular check-ups to monitor how well the treatment worked and watch for any side effects.

AI-generated summary from trial data · Jun 24, 2026 · Not medical advice

Trial locations(42 sites)

Ireland

Bon Secours Radiotherapy Cork in partnership with UPMC Hillman Cancer Centre, Cork

St Lukes Radiation Oncology Network, Dublin

Mid Western Radiation Oncology Centre, Limerick

New Zealand

Auckland Hospital, Auckland

United Kingdom

James Cook University Hospital, Middlesbrough, South Tees