Plain-English translation of NCT05637086 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Epilepsy research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether two medications—pentoxifylline and celecoxib—can help control seizures better when added to , a standard epilepsy medication you may already be taking. Researchers believe these add-on medications might reduce inflammation in the brain, which is thought to play a role in seizures. The study will compare your seizure control and safety on alone versus plus one of these two additional treatments over six months.
Epilepsy happens when there's abnormal electrical activity and inflammation in the brain. While helps control seizures, some people still experience breakthrough seizures or side effects. This medication may reduce brain inflammation in a new way, potentially giving patients better seizure control with their current treatment.
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You would be randomly assigned to one of three groups: taking your current alone, plus pentoxifylline twice daily, or plus celecoxib once daily. You'll continue this regimen for six months while researchers monitor your seizure frequency, side effects, and how well you're tolerating the medication. You'll likely have regular check-in visits to report how you're doing and possibly have blood tests to ensure the treatment is safe for you.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
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