Recruiting

Radiation and Electric Fields for Advanced Pancreatic Cancer

Plain-English translation of NCT05679674 on ClinicalTrials.gov ↗ · Source last updated January 2026 · Translation generated July 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing a combination of two treatments for locally advanced pancreatic cancer: a specialized form of radiation therapy called stereotactic ablative body radiation therapy (SABR), plus a wearable device called tumor treating fields (TTF) that delivers mild electric currents to the tumor area. You would receive the radiation once daily for five days, and wear the electric field device for at least 18 hours each day starting on day one of radiation and continuing as long as the treatment is helping.

Pancreatic cancer that hasn't spread beyond the local area is very hard to treat, and current standard therapies don't work well enough for many patients. Researchers believe that combining focused radiation with the electric field device might work better together to slow or stop tumor growth.

Do you qualify?

You likely qualify if…

you have been diagnosed with locally advanced pancreatic cancer (cancer that hasn't spread to distant organs)
you have completed at least 3 months of prior chemotherapy for pancreatic cancer without the cancer spreading further
you are in generally good health and able to care for yourself, with only minor limitations
your recent blood work shows adequate liver, kidney, and blood cell function
you are able to operate or be helped to operate the electric field device
if you can have children, you agree to use reliable birth control during the trial

You likely don't qualify if…

you have cancer that has spread to distant organs (distant metastasis)
you cannot have an MRI scan due to metal implants or other medical reasons
you have had radiation therapy to your abdomen before
you have an implanted electrical device in your chest or abdomen, such as a pacemaker or spinal cord stimulator
you have inflammatory bowel disease like Crohn's disease or ulcerative colitis

What participation looks like

You would come to the hospital or radiation center once per day for five consecutive days to receive the focused radiation treatment. At the same time, you would begin using the electric field device, wearing it under your clothing for at least 18 hours each day. You would continue wearing the device every day until your cancer progresses or side effects become too severe. Throughout the trial, you'll have regular check-ups, blood tests, and imaging scans to monitor how well the treatment is working and how you're tolerating it.

AI-generated summary from trial data · Jul 21, 2026 · Not medical advice

Trial locations(1 site)

United States

Miami Cancer Institute at Baptist Health, Inc., Miami, Florida