Plain-English translation of NCT05802121 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Prostate Cancer research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Men with advanced prostate cancer often take hormone-lowering treatment (called ADT) to slow their cancer, but this treatment can cause serious side effects like weight gain, high cholesterol, diabetes, and weak bones. This trial tests whether capsules can help prevent these side effects by increasing a helpful bacteria in your gut. You would take one capsule daily for 3 months and have your blood, bones, and stool checked to see if the treatment works.
Hormone-lowering treatment for prostate cancer saves lives but causes metabolic problems that can harm men's health long-term. Researchers think increasing a specific gut bacteria using this medication might naturally protect against these harmful side effects, but this hasn't been properly tested yet.
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If you qualify, you will be randomly assigned to either take one capsule by mouth every day for 3 months, or to continue with standard cancer care without the supplement. During the study, you will provide stool samples and blood samples so researchers can check if the bacteria in your gut has changed and measure your cholesterol, blood sugar, bone health, and weight. The study lasts 3 months, and the main thing you do is take the daily capsule and attend appointments for testing.
AI-generated summary from trial data · Aug 11, 2026 · Not medical advice
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