Recruiting

Partial prostate removal surgery to preserve function in early-stage cancer

Plain-English translation of NCT05832736 on ClinicalTrials.gov ↗ · Source last updated September 2023 · Translation generated June 2026 · How we translate trials

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This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing robotic-assisted partial prostate removal surgery in men with early-stage prostate cancer that affects only one side of the prostate gland. The goal is to see whether this approach can successfully control the cancer while causing less damage to urinary control and sexual function compared to removing the entire prostate. Researchers believe this technique may offer men with specific types of early-stage cancer a way to preserve quality of life while still treating their disease effectively.

Standard prostate cancer treatment often involves removing the entire prostate, which can lead to problems with urinary control and sexual function that significantly affect men's quality of life. This trial exists to test whether removing only the cancerous side of the prostate can achieve the same cancer control with fewer side effects, giving men with early-stage disease a potentially better option.

Do you qualify?

You likely qualify if…

you have been diagnosed with prostate cancer that affects only one side of the prostate
your PSA level is below 20 ng/mL at diagnosis
imaging tests (MRI or PET-PSMA scan) confirm the cancer is contained within the prostate and has not spread
your biopsy shows the cancer is a common type (acinar-type) with a low-to-intermediate grade (ISUP grade less than 3)
you are in good overall health with a life expectancy of at least 5 years
you are able and willing to attend follow-up appointments as required by the study

You likely don't qualify if…

you have had previous prostate surgery such as TURP (transurethral resection) or other procedures
you cannot have an MRI scan (for example, due to a pacemaker or severe claustrophobia) and cannot have a PET-PSMA scan instead
you have cancer that has spread to lymph nodes, bones, or other organs
you have serious medical conditions or active infections that are not well controlled
you have dementia or psychiatric conditions that would prevent you from understanding the study or following the protocol

What participation looks like

If you qualify and enroll, you would undergo robotic-assisted surgery to remove only the cancerous side of your prostate while preserving the urethra (the tube that carries urine). Before surgery, you will have detailed imaging and clinical assessments. After surgery, you will attend scheduled follow-up visits to monitor your recovery, cancer control, and how well your urinary and sexual function are preserved. The study will track your progress over an extended period to ensure the surgery achieves good cancer control with minimal impact on your quality of life.

AI-generated summary from trial data · Jun 24, 2026 · Not medical advice

Trial locations(1 site)

Italy

Fondazione del Piemonte per l'Oncologia, Candiolo, TO