Plain-English translation of NCT05873192 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Prostate Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether , combined with and hormone therapy, can help shrink prostate cancer before surgery. Men newly diagnosed with prostate cancer that has spread to lymph nodes will receive this combination of medications for several months, then have surgery to remove the prostate. The goal is to see if the medication can reduce cancer cells enough to make the cancer undetectable one year after surgery.
For men with prostate cancer that has spread to lymph nodes, surgery alone may not be enough to control the disease. Researchers want to know if giving this medication before surgery can improve outcomes by shrinking the cancer first.
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You will first receive hormone therapy and together for about 8 weeks. After those 8 weeks, you will start taking along with the other medications. You will have regular blood tests, imaging scans, and check-ins with your doctors throughout this treatment period. Once the doctors see that the cancer has responded well to the medication, you will undergo surgery to remove your prostate. After surgery, you will be followed with blood tests to monitor your cancer for at least one year, and researchers will track your health for up to five years to see how well the treatment worked.
AI-generated summary from trial data · Jul 9, 2026 · Not medical advice
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