Preventing cognitive decline and job loss in multiple sclerosis

This trial is testing two different early intervention approaches to help people with multiple sclerosis prevent or delay cognitive decline—problems with thinking, memory, and focus—and avoid early job loss. One approach combines fitness training, dietary advice, and cognitive exercises; the other provides personalized work coaching to solve job-related challenges. Both are compared to standard care to see which helps people maintain their quality of life best.

Up to 65% of people with MS develop thinking and memory problems that seriously affect their daily lives, and about 65% lose their jobs within five years of diagnosis. Current treatments usually step in after problems have already started, so this study is testing whether starting interventions early—before major problems develop—can prevent or delay these issues and help people stay working and independent.