Plain-English translation of NCT06084338 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Prostate Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether combining two treatments — stereotactic body radiation therapy (a precise form of radiation that targets tumors directly) and (a specialized treatment that finds and attacks cancer cells using radioactive molecules) — can help men with advanced prostate cancer. The study also explores whether stopping hormone-suppressing medications and, in some cases, restoring natural testosterone levels might improve outcomes.
Currently, men with advanced prostate cancer that has stopped responding to hormone therapy have limited options. This trial explores whether using targeted radiation combined with this specialized treatment, while stopping hormone suppression, could offer a better approach with fewer side effects.
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You would receive radiation therapy targeting all visible tumors, followed by the specialized immunotherapy treatment. One group would then stop their hormone-suppressing medication, while another group would stop it and receive testosterone replacement. You'll have blood tests and imaging scans to monitor how you're responding, and you'll need to use contraception for several months during and after treatment.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
United States