Targeted radiation therapy for early prostate cancer, with or without hormone therapy

The University of Miami UAdapt Trial is testing a new approach to prostate cancer treatment using MRI-guided stereotactic radiation therapy (a highly precise form of radiation that targets only the tumor, not the entire prostate). The trial is comparing this focused radiation alone versus radiation combined with short-term hormone therapy, and testing whether this approach works for different risk levels of prostate cancer.

Standard prostate cancer treatment often involves treating the entire prostate gland, which can cause side effects affecting quality of life. This trial is exploring whether treating only the tumor itself—while possibly boosting the immune system—can be just as effective while reducing harm to surrounding healthy tissue.