Walking improvement by combining a medication with physical therapy for multiple sclerosis

This trial is testing whether dalfampridine—a medication that helps nerve signals travel better in the brain and spinal cord—works better when combined with hands-on physical therapy to improve walking. Many people with multiple sclerosis struggle with walking, and this study wants to see if using this medication alongside specialized physical therapy can help more than using either treatment by itself.

Walking problems affect most people with multiple sclerosis, and while this medication and physical therapy have both been shown to help separately, no one has studied what happens when you combine them. Researchers believe that this medication might actually help the brain learn and adapt better during physical therapy, making the benefits last longer.