Combining a walking medication with physical therapy for multiple sclerosis

This trial is testing whether dalfampridine—a medication that helps improve nerve signal transmission—works better when combined with physical therapy to improve walking ability in people with multiple sclerosis. The medication alone helps some people walk better, but the benefits fade once you stop taking it. Researchers believe that combining the medication with targeted physical therapy might create longer-lasting improvements by helping your brain and nervous system learn and adapt alongside the medication's benefits.

Walking problems affect more than 9 out of 10 people with multiple sclerosis, and while physical therapy and this medication each help individually, no one has tested whether using them together might produce better results. The study aims to see if the medication's benefits could work synergistically with physical therapy to create more lasting improvements.