Plain-English translation of NCT06143293 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Epilepsy research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is called REVEAL, and it studies how vagus nerve stimulation (VNS)—a surgically implanted device that sends mild electrical pulses to a nerve in your neck—affects your body. Researchers want to understand exactly how this device works on your heart, immune system, metabolism, and other body functions. This is not a treatment study; instead, scientists are gathering detailed information about the device's effects in people who already have it implanted for epilepsy or depression.
Even though vagus nerve stimulation is already being used to treat drug-resistant epilepsy and severe depression, doctors don't fully understand all the ways it affects the body's different systems. This research aims to fill that gap so doctors can optimize treatment and potentially help more patients.
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If you join this study, you will receive your standard vagus nerve stimulation device care, and researchers will test it at different stimulation frequencies (1Hz, 10Hz, and 30Hz) during different study periods. You will attend multiple study visits where doctors will take blood samples and measure your heart rate, breathing, and other body responses using non-invasive monitors. The study compares how your body reacts to these different stimulation settings to help scientists understand how the device affects your overall health.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
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