Plain-English translation of NCT06303622 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Prostate Cancer research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
The PROFUSION Trial is testing two different approaches to prostate biopsy in men who have suspicious lesions (areas of concern) on MRI imaging. One approach uses computer software to blend MRI and ultrasound images together to guide the biopsy needle precisely, while the other relies on the doctor's experience and mental visualization to guide the needle. This trial will help determine which method is better at finding clinically significant prostate cancer.
Prostate biopsies are necessary when there are suspicious areas on imaging, but doctors want to know the most accurate way to sample these areas. This trial will determine whether the newer computer-assisted fusion technology leads to better cancer detection compared to the traditional doctor-guided approach, which could change how prostate biopsies are performed worldwide.
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If you join this trial, you will be randomly assigned to receive a prostate biopsy using either the computer-assisted fusion method or the doctor-guided method. Both approaches involve taking tissue samples from your prostate using an ultrasound probe inserted into the rectum — the main difference is how the doctor finds and targets the suspicious areas. The biopsy itself will be performed once, and you will then be monitored for the results.
AI-generated summary from trial data · Jul 12, 2026 · Not medical advice
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