Plain-English translation of NCT06398613 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Prostate Cancer research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a new imaging scan called PSMA PET/CT can help doctors make better decisions about prostate cancer surgery. The scan looks for cancer spread to lymph nodes in the pelvis. The study will compare two approaches: one where all eligible patients get extended lymph node removal during surgery, and another where the imaging scan guides the decision — patients only get lymph node removal if the scan shows suspicious nodes.
Currently, doctors often remove extended pelvic lymph nodes during prostate cancer surgery to check for cancer spread, but this adds surgical time and potential side effects. This trial is testing whether the new imaging scan can accurately identify which patients actually need this extended removal, potentially sparing others from unnecessary surgery while still catching all cases of cancer spread.
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If you enroll, you will first undergo the PSMA PET/CT imaging scan, which takes a few hours and involves receiving an injection of a tracer substance followed by scanning. You will then be randomly assigned to one of two groups: one group will have extended lymph node removal along with prostate removal surgery, while the other group's decision about lymph node removal will depend on what the imaging scan shows. After surgery, you will have follow-up visits over 2 years to check for cancer recurrence through blood tests and clinical assessments.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
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