Targeted radiation therapy for large pancreatic tumors near vital organs

This trial is testing a new radiation therapy technique called central-boost ablative radiation therapy (CBART) for pancreatic cancer patients whose tumors are too large or too close to vital organs to be removed surgically. The treatment uses advanced imaging and precise radiation beams to deliver higher, more focused doses to the center of the tumor while protecting nearby healthy tissue. Researchers want to see if this approach can effectively shrink tumors and control symptoms while remaining safe.

Many pancreatic cancer patients have tumors that are too large or positioned too close to vital organs like the stomach or intestines to be surgically removed. Standard radiation therapy alone cannot deliver strong enough doses to these tumors because it would damage the surrounding organs. This new treatment is designed to overcome that problem by concentrating the highest radiation doses in the tumor's core while sparing nearby healthy tissue.