Plain-English translation of NCT06451445 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Prostate Cancer research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a treatment called Irreversible Electroporation (IRE) using the NanoKnife System for men with intermediate-risk prostate cancer. The treatment uses high-voltage electrical energy delivered through thin probes to destroy cancer cells in a targeted area of the prostate. Because it spares blood vessels and nearby sensitive structures, this approach may offer benefits compared to conventional surgery or radiation therapy.
Men with intermediate-risk prostate cancer are often treated with surgery or radiation, both of which can cause serious side effects like incontinence and sexual dysfunction. This trial exists to see if this newer electrical energy treatment can be effective while causing fewer of these complications.
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You would receive the electrical energy treatment under general anesthesia as an outpatient procedure. After treatment, you would return to the clinic for follow-up visits at 1, 3, 6, 9, and 12 months to check how well the treatment worked. At these visits, you would have imaging scans and may have a repeat biopsy at the 12-month mark to confirm the cancer has been treated.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
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