Plain-English translation of NCT06505421 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Multiple Sclerosis research guide →This study is testing whether eccentric strength training—a special type of exercise where muscles work while being stretched under resistance—might be better than traditional strength training for people with multiple sclerosis who struggle with fatigue. The researchers want to see if eccentric training can build strength with less tiredness, since fatigue is one of the biggest challenges in MS.
People with MS often feel too exhausted to exercise, even though exercise helps with mobility problems. Traditional strength training requires a lot of energy, which makes fatigue worse. This study exists to see if eccentric training could be a better option because it builds strength more efficiently—using less energy overall.
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You'll visit the research site twice, about a week apart. Each visit, you'll do one type of leg strength training exercise (either eccentric or traditional), and the next day you'll return to report how tired you feel. The second week, you'll come back and try the other type of training, then report your fatigue level again. The whole study takes about 2 weeks to complete.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United States
Hunter College of City University of New York
Enrollment target
~30 participants
Started
July 2024
Primary completion
December 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 75 Years
Last updated on clinicaltrials.gov in July 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Herbert Karpatkin, DSc
Hunter College of City University of New York
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.