Recruiting

Comparing Two Biopsy Methods to Detect Prostate Cancer

Plain-English translation of NCT06517901 on ClinicalTrials.gov ↗ · Source last updated October 2025 · Translation generated July 2026 · How we translate trials

Read our Prostate Cancer research guide →

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether two different techniques for performing prostate biopsies are equally good at detecting clinically significant prostate cancer. Both methods use an MRI scan to guide the biopsy, but they do it in slightly different ways: one uses computer software to fuse MRI and ultrasound images together, and the other uses the doctor's visual judgment and measurements to guide the biopsy needle. The study wants to find out which approach is better at finding cancer.

Right now, doctors aren't sure whether one biopsy technique is better than the other at detecting prostate cancer. Research so far has been mixed and not high quality enough to give doctors a clear answer. This larger, well-designed study should help determine which method works best.

Do you qualify?

You likely qualify if…

you are a man who needs a prostate biopsy to check for suspected prostate cancer as part of your regular medical care
you have had an MRI scan of your prostate before the biopsy that shows one or more suspicious areas
you have not had a prostate biopsy in the past 3 years, or this will be your first one
your prostate-specific antigen (PSA) blood test level is 20 or lower, or you have an abnormal digital rectal examination
the suspicious areas found on your MRI are 2 centimeters or smaller in size

You likely don't qualify if…

you have suspicious areas on your MRI that are larger than 2 centimeters
you have had a prostate biopsy within the past 3 years
you have already been diagnosed with prostate cancer
you currently have a fever, urinary tract infection, or other conditions that would make biopsy unsafe

What participation looks like

If you join this study, you will undergo a prostate biopsy using one of the two methods being tested. Your doctor will have already done an MRI scan of your prostate before your biopsy appointment. During the biopsy itself, you'll receive either the computer-guided fusion technique or the doctor-guided cognitive technique to help collect tissue samples from the suspicious areas. The study team will then compare how well each method detected cancer and track your results.

AI-generated summary from trial data · Jul 21, 2026 · Not medical advice

Comparing Two Biopsy Methods to Detect Prostate Cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations(4 sites)