Plain-English translation of NCT06539806 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Pancreatic Cancer research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers are studying whether losartan, a medication commonly used to treat high blood pressure, might help improve how well chemotherapy works against pancreatic cancer. Your body has a natural system called the renin-angiotensin system that helps control blood pressure, but this same system may also encourage cancer cells to grow and spread. The study tests whether blocking this system with losartan could make chemotherapy more effective.
Pancreatic cancer is very aggressive and spreads quickly, which is why survival rates are currently very low. Scientists have discovered that the renin-angiotensin system may play a role in helping cancer cells grow and travel to other parts of the body. This trial explores whether this medication could help stop that process and make standard cancer treatment work better.
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You would receive standard chemotherapy (called Folfirinox) along with losartan 50 mg taken by mouth once daily. Depending on which group you join, you may start losartan before or after your cancer diagnosis. The study follows you for one year after your cancer diagnosis, during which time your blood pressure, cancer response, and any side effects would be monitored regularly through clinic visits and tests.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
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