Recruiting

Targeted radiation therapy using MRI imaging for intermediate prostate cancer

Plain-English translation of NCT06542757 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated July 2026 · How we translate trials

Read our Prostate Cancer research guide →

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing a new approach to treating intermediate-risk prostate cancer using MR-guided radiotherapy—a type of radiation treatment that uses real-time MRI imaging to target cancer more precisely. Instead of treating the entire prostate equally, this treatment delivers a higher dose of radiation to the main tumor (called the dominant lesion) while giving a lower dose to the rest of the prostate. The goal is to improve how well the cancer is controlled while reducing side effects.

Current prostate cancer treatment typically treats the entire prostate gland with the same dose of radiation. This trial exists because doctors believe they can do better by focusing more radiation on the area where the cancer is actually growing, which might kill cancer cells more effectively while sparing healthy tissue from unnecessary radiation.

Do you qualify?

You likely qualify if…

you have been diagnosed with intermediate-risk prostate cancer (based on PSA level, Gleason score, or tumor stage)
you are over 18 years old and in good enough health to tolerate treatment
you have a visible dominant tumor in your prostate that is at least 0.5 cm in size
your prostate is smaller than 90 cubic centimeters
you do not have urinary symptoms that are too severe (as measured by a standard symptom score)
you are able to have MRI scans and willing to complete follow-up visits and quality-of-life surveys

You likely don't qualify if…

you have high-grade cancer (Gleason score higher than 7)
your PSA level is above 20 ng/mL
you have signs that the cancer has spread outside the prostate or to other parts of your body
you have metal implants (like a pacemaker or certain joint replacements) that make MRI unsafe for you
you have a history of previous pelvic radiation or certain prostate surgeries

What participation looks like

You would receive five radiation treatments over two weeks (every other day, Monday through Friday), each lasting about 30 minutes. One week before starting radiation, you would have a procedure to place a spacer gel between your prostate and rectum to protect healthy tissue. You would have MRI scans before and during treatment to guide the radiation precisely. After treatment ends, you would have follow-up visits at 3 months, 6 months, and then every 6 months for up to 2 years, including additional MRI scans and biopsies to check how well the cancer was controlled.

AI-generated summary from trial data · Jul 3, 2026 · Not medical advice

Targeted radiation therapy using MRI imaging for intermediate prostate cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)