Recruiting

Testing a new medication before prostate cancer surgery

Plain-English translation of NCT06613100 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated June 2026 · How we translate trials

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Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This trial is testing a new drug called to see if it is safe and tolerable when given before surgery to remove the prostate in men with newly diagnosed, intermediate or high-risk prostate cancer. Some participants will receive alone, while others will receive the medication combined with an oral hormone blocker pill. The study will also check whether it is safe and feasible to perform surgery after this medication treatment.

Men with intermediate or high-risk localized prostate cancer need better treatment options to improve their chances of long-term survival and reduce cancer spread. This trial is exploring whether giving this new medication before surgery might help shrink the cancer, kill cancer cells, or improve surgical outcomes.

Do you qualify?

You likely qualify if…

you have been diagnosed with intermediate or high-risk prostate cancer that has not spread outside the prostate area
you are planned to undergo surgery to remove your prostate
you have not received any prior treatment for your prostate cancer (except that participants in one group may have taken a hormone pill for up to 3 months before the study starts)
you have had a PSMA-PET scan (a special imaging test) within the last 3 months as part of your standard cancer care
you are in generally good health with minimal limitations on your daily activities

You likely don't qualify if…

you have evidence that your cancer has spread outside the area where surgery would remove it
you have an active infection that requires antibiotics within 7 days before starting the study medication
you have a history of blood clots (stroke, heart attack, or lung clots) within the last 3 to 12 months, depending on the type
you have had a recent heart attack or heart failure within the past 12 months
you are currently enrolled in another clinical trial or were enrolled in one within the last 4 weeks

What participation looks like

If you join this study, you will receive the new medication (either alone or combined with a hormone pill) for a period of time before your scheduled prostate cancer surgery. You will have regular visits for safety checks, imaging scans, and blood work to monitor how you are responding. After completing the medication phase, you will proceed with your planned surgery to remove the prostate, and researchers will follow up to ensure the surgery went well and to monitor your recovery.

AI-generated summary from trial data · Jun 9, 2026 · Not medical advice

Trial locations(9 sites)

United States

University of California San Francisco, San Francisco, California

Washington University, St Louis, Missouri

The Ohio State University, Columbus, Ohio

Thomas Jefferson University, Philadelphia, Pennsylvania

Carolina Urologic Research Center, Myrtle Beach, South Carolina