Testing Two Different Prostate Biopsy Methods for Multiple Suspicious Areas

Prostate cancer diagnosis often requires a biopsy—a procedure where small samples of tissue are taken from the prostate. This trial is testing whether a newer biopsy approach called targeted and perilesional biopsy works as well as (or better than) the traditional combined approach. The goal is to find the method that catches cancer most accurately while taking fewer tissue samples and causing fewer complications.

Currently, when doctors find multiple suspicious areas on MRI scans, they use a standard biopsy method that may collect more samples than needed and sometimes finds cancers that don't need treatment. This trial wants to know if focusing the biopsy samples more strategically around the suspicious areas can be just as effective while reducing unnecessary sampling and post-procedure problems.