Plain-English translation of NCT06901687 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Multiple Sclerosis research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether transcranial direct current stimulation (tDCS)—a non-invasive device that delivers mild electrical currents to the brain—can help reduce depression in people with multiple sclerosis. Participants will use the device at home for 30 minutes each day over one month while listening to mindfulness meditation. Half of the participants will receive active treatment, and half will receive a placebo (sham) treatment, with neither the participants nor the researchers knowing who gets which until the end.
Depression is very common in people with multiple sclerosis and can be difficult to treat with medications alone. This trial is exploring whether this non-invasive brain stimulation technique could be a new way to help reduce depression symptoms while allowing patients to stay at home.
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If you enroll, you'll use a small tDCS device at home for 30 minutes each day, five days a week, for one month. During each session, you'll wear the device on your scalp while listening to a guided mindfulness meditation. You'll participate in remote video check-ins with the research team to make sure everything is going well. Throughout the study, you'll complete surveys and assessments about your mood and MS symptoms to help the researchers understand how the treatment is working.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
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