Plain-English translation of NCT07041619 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Epilepsy research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a device called Intersectional Short Pulse (ISP) stimulation, which uses surgically implanted electrodes placed under the scalp to deliver electrical pulses to the brain. The goal is to detect seizures as they start and deliver stimulation to reduce their severity, duration, or stop them entirely. This treatment is being tested in adults with focal epilepsy that hasn't responded well to medications.
Many people with epilepsy continue to have seizures even when taking multiple anti-seizure medications. For some patients, surgery to remove the area causing seizures isn't an option. This trial explores whether precisely targeted electrical stimulation can help control seizures in patients for whom current treatments haven't worked well.
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You will undergo MRI scans to map your brain anatomy for precise electrode placement. Then, under general anesthesia, surgeons will implant small electrodes under your scalp. After surgery, you'll have continuous EEG monitoring to track your baseline seizures, followed by testing sessions where the electrical stimulation is activated at safe, tolerable levels. An advanced computer system will detect when seizures begin and automatically trigger stimulation to target them. Throughout the study, your safety and any changes in seizure frequency or severity will be closely monitored. At the end of the trial period, the electrodes will be surgically removed, and you'll have follow-up visits to ensure you're healing well.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
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