Plain-English translation of NCT07100847 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our PROSTATE CANCER research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a treatment called periprostatic neurolysis, which uses ethanol injections to block the nerves around the prostate. Researchers believe that cancer cells travel along these nerves to spread to other parts of the body, so blocking them might help prevent that spread. The study will compare whether one injection works better than two injections at reducing these nerve connections.
High-risk prostate cancer spreads to the bones in 9 out of 10 cases, and researchers have discovered that cancer cells travel along the nerves that connect the prostate to the spine. This trial exists to test whether blocking these nerves can prevent that spread and improve outcomes for men with aggressive prostate cancer.
You would be randomly assigned to receive either one ethanol injection around the prostate, two ethanol injections over time, or no injection (control group). The injections are given during a procedure performed before your scheduled prostate removal surgery. Your prostate tissue will then be examined after surgery to see how well the treatment reduced nerve density, and you'll be followed to monitor your health and cancer outcomes.
AI-generated summary from trial data · Jul 17, 2026 · Not medical advice
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