Receive a single high-dose radiation treatment for prostate cancer

Receive a single high-dose radiation treatment for prostate cancer | stella

What is this trial?

This trial is testing a new approach called single-dose radiotherapy (SDRT) for men with early-stage prostate cancer. Instead of receiving multiple radiation sessions over weeks, you would receive one carefully planned, high-dose radiation treatment delivered with advanced imaging and special immobilization devices to keep your prostate in the exact same position and protect surrounding healthy tissue. Recent research suggests this single-treatment approach may work as well as traditional multi-session radiation therapy, but with much greater convenience.

Standard prostate cancer radiation requires multiple sessions over several weeks, which is time-consuming and burdensome for patients. Earlier trials showed that a single high-dose treatment may be just as effective with fewer side effects, but more research is needed to confirm this approach is safe and works reliably in clinical practice.

Do you qualify?

You likely qualify if…

you have been diagnosed with prostate cancer that is confirmed by biopsy with a Gleason score of 7 or lower
your cancer has not spread to lymph nodes or other parts of your body
your prostate-specific antigen (PSA) level is 20 or lower
your prostate gland is not too enlarged (100 cubic centimeters or smaller)
you have not received previous pelvic radiation or prostate surgery
you are at least 18 years old and in reasonably good overall health

You likely don't qualify if…

you have advanced prostate cancer (stage T3 or T4) or cancer that has spread to lymph nodes or distant organs
you have a Gleason score higher than 7
you have received pelvic radiation therapy or prostate surgery in the past
you have a history of another cancer (unless you have been disease-free for at least 3 years)
you have had a transurethral resection of the prostate (TURP) procedure within the last 3 months

What participation looks like

If you enroll, you will receive careful planning scans and imaging to map your prostate precisely. On treatment day, a small air-filled balloon will be placed in your rectum and a catheter in your urethra to keep your prostate in the exact position during treatment. You will then receive a single, focused high-dose radiation beam delivered by advanced imaging-guided equipment, and the entire process takes about 30 minutes to an hour. After treatment, you will have follow-up visits to monitor for side effects and to confirm the treatment is working.

AI-generated summary from trial data · Jun 12, 2026 · Not medical advice

Single high-dose radiation treatment for early-stage prostate cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)