Radiation therapy for prostate cancer spread to a few sites

This trial is testing a treatment approach for men with prostate cancer that has spread to only a few sites in the body (typically 5 or fewer spots outside the pelvis). Most participants will receive a combination of hormone therapy, additional cancer-fighting medication, and targeted radiation therapy (delivered with high doses aimed directly at the cancer spots). The study wants to see how well this combination works and whether special imaging scans called PSMA-PET can help doctors predict which patients will do well and which might have their cancer come back.

Prostate cancer that has spread to only a few places is sometimes treated differently than cancer that has spread widely, because doctors may be able to target each spot directly. This trial exists to figure out whether combining radiation therapy with medications can better control the cancer in these early-spread situations, and to see if new imaging tests can help doctors make better treatment decisions.