Plain-English translation of NCT07342777 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Multiple Sclerosis research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
The EXpain trial is testing whether structured strength training exercises can help reduce chronic pain in people with multiple sclerosis. Researchers want to understand how exercise affects different types of pain and whether the benefits last after the program ends. This study involves 116 participants with MS who experience chronic pain.
Many people with MS struggle with chronic pain that affects their quality of life, sleep, and daily activities, but pain-relieving medications don't work well for everyone. This trial is exploring whether exercise—a non-medication approach—could be an effective way to help manage pain and potentially improve overall well-being.
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Participants are divided into two groups. One group starts with 12 weeks of guided progressive strength training exercises, followed by 12 weeks of regular care. The other group receives 24 weeks of usual care first, then does 12 weeks of strength training. Throughout the study, researchers assess pain levels, physical activity, sleep quality, mood, and how pain affects daily life. The entire study lasts 24 weeks.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
Denmark
Sponsor
University of Aarhus
Collaborators
Aalborg University
Enrollment target
~116 participants
Started
January 2026
Primary completion
July 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in January 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Rasmus C Jungersen, PhD-student
University of Aarhus
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.