Recruiting

Testing two radiation schedules for aggressive prostate cancer

Plain-English translation of NCT07407608 on ClinicalTrials.gov ↗ · Source last updated February 2026 · Translation generated June 2026 · How we translate trials

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What is this trial?

ABRUPT 2.0 is testing two different ways to deliver radiation therapy to treat prostate cancer that is more aggressive than average. One approach gives you a very high dose of radiation in just one session, while the other spreads five smaller radiation doses over two weeks. Both approaches use advanced imaging to target the tumor precisely while protecting healthy tissue nearby.

Doctors want to find the safest and most effective way to treat aggressive prostate cancer with radiation. This trial compares two newer, faster radiation schedules to see which one causes fewer side effects while still effectively treating the cancer.

Do you qualify?

You likely qualify if…

you have been diagnosed with prostate cancer (adenocarcinoma) that is intermediate or high-risk according to standard medical guidelines
your cancer is confined to the prostate with no signs of spread to lymph nodes or distant organs
your prostate tumor shows up clearly on an MRI scan
you are in generally good health with a life expectancy of more than 5 years
you have mild to moderate urinary symptoms (a score of 15 or less on a standard symptom scale, and you may be taking medications to help)
your prostate gland is not too enlarged (100 grams or smaller)

You likely don't qualify if…

you have very advanced prostate cancer (T3b stage or higher)
your PSA level is above 20 ng/mL
you have had previous surgery or radiation treatment to your prostate or pelvis
you have active inflammatory bowel disease such as Crohn's disease or ulcerative colitis
you have a hip replacement that might interfere with radiation positioning

What participation looks like

You will have imaging scans (CT and MRI) done on the same day to map your prostate and tumor precisely. Then you will be randomly assigned to one of two groups: either receive one large radiation treatment, or receive five smaller radiation treatments over two weeks. For each treatment, you'll be positioned on a table for the radiation delivery. The study will monitor you closely for side effects, particularly any urinary symptoms, which doctors will track as part of the trial.

AI-generated summary from trial data · Jun 12, 2026 · Not medical advice

Testing two radiation schedules for aggressive prostate cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations