Learn Data Labs For Researchers Find trials matched to me

Learn Data Labs For Researchers Find trials matched to me →

Clinical trial discovery in plain English. Data sourced from ClinicalTrials.gov.

About Privacy ClinicalTrials.gov ↗

Stella is not a medical provider and does not give medical advice. AI-generated summaries are for informational purposes only. Always consult your doctor before making any healthcare decisions.

Complete follow-up MRI scans to help improve MS diagnosis methods | stella

Back to Multiple Sclerosis trials

Recruiting

Long-term MRI scan study to improve multiple sclerosis diagnosis

Plain-English translation of NCT07424027 on ClinicalTrials.gov ↗ · Source last updated February 2026 · Translation generated June 2026 · How we translate trials

Read our Multiple Sclerosis research guide →

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

Researchers are studying a specific pattern visible on MRI scans called the Central Vein Sign to see if it can help doctors diagnose multiple sclerosis more reliably. This is a follow-up study that will track people who participated in an earlier research project, checking in at the 4-year mark to see how well this MRI pattern works for diagnosis and what it might predict about the disease over time.

Currently, diagnosing MS can take a long time, especially in patients with unusual symptoms. This MRI pattern shows promise for speeding up diagnosis and distinguishing MS from other conditions that look similar, but researchers need long-term data to confirm it works as well as they hope.

Do you qualify?

You likely qualify if…

you participated in the earlier CAVS-MS study and completed all visits through month 24
you have either a confirmed diagnosis of MS or are at risk for MS from the earlier study
you are able to provide written consent to participate in this follow-up study
you are able to undergo an MRI scan

You likely don't qualify if…

you have metal implants or metal in your body that are not compatible with MRI machines
you have severe claustrophobia or cannot hold still for an MRI scan
you did not complete the earlier CAVS-MS study

What participation looks like

If you join this study, you will return to one of three participating medical centers for follow-up visits around the 4-year mark after your original enrollment. You will have an MRI scan of your brain, similar to what you had in the earlier study, so researchers can see if the MRI pattern they are tracking changes over time and what it tells them about your MS or MS risk.

AI-generated summary from trial data · Jun 10, 2026 · Not medical advice

Trial locations(3 sites)

United States

Cedars-Sinai Medical Center, Los Angeles, California

Cleveland Clinic Foundation, Cleveland, Ohio

University of Pennsylvania, Philadelphia, Pennsylvania

Key details

Sponsor

The Cleveland Clinic

Collaborators

Cedars-Sinai Medical Center, University of Pennsylvania

Enrollment target

~40 participants

Started

October 2025

Primary completion

December 2026

Age range

18 Years – 65 Years

Last updated on clinicaltrials.gov in February 2026.

Contact the research team directly

Reach out to the team running this trial. Response times vary — some teams are faster than others.

Central contact

Meghan Kilbane

The Cleveland Clinic

Interested in joining?

Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.

Follow this trial

Get notified in plain English when this trial's status changes. No account required.

View full record on ClinicalTrials.gov