Testing a citrus supplement to ease fatigue and thinking problems in MS

This study is testing whether hesperidin—a natural compound found in citrus fruits like oranges and lemons—can help reduce fatigue, improve mood, and support clearer thinking in people with MS. In animal studies, hesperidin showed promise in reducing inflammation and oxidative stress, which are thought to contribute to MS symptoms. This trial will give some participants the medication and others a placebo (a pill with no active ingredient) to see if the treatment actually works in people.

While there are disease-modifying treatments for MS, many people still struggle with debilitating fatigue and cognitive problems that affect daily life. This medication may offer a simple, low-risk option to manage these difficult symptoms alongside standard MS treatments, but it needs to be tested properly in people first.