Plain-English translation of NCT07455903 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Prostate Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether giving hormone-blocking medication before prostate surgery helps treat high-risk prostate cancer more effectively. You'll receive one of four types of androgen deprivation therapy (ADT) for 6 months, then have special imaging scans to see how well the medication worked, and finally undergo prostate surgery. The study wants to learn if measuring changes on these scans can predict which patients will have the best long-term outcomes.
High-risk prostate cancer is aggressive and can come back even after surgery. Doctors hope that giving this medication beforehand will shrink the cancer and improve survival rates, but they need to find the best way to measure whether the treatment is actually working.
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You will receive hormone therapy for 6 months, either as injections given by a nurse every 3 months, injections under the skin every 28 days, or a daily pill—your doctor will choose which works best for you. You'll have a special PET imaging scan at the start and again after 6 months of treatment to measure how well the medication is working. After completing the imaging, you'll undergo prostate surgery to remove the cancer. The entire process takes about 6–7 months from start to finish.
AI-generated summary from trial data · Aug 20, 2026 · Not medical advice
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