Plain-English translation of NCT07455903 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Prostate Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether giving hormone-blocking medications (like , , , or ) before prostate surgery can help men with advanced, high-risk prostate cancer. You'll receive the medication for 6 months, get special imaging scans before and after treatment to measure how well it's working, and then have surgery to remove your prostate.
Doctors want to understand whether shrinking the cancer with hormone therapy before surgery improves long-term outcomes for men with aggressive prostate cancer, and whether the imaging scans can predict which patients will do best.
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You'll start hormone-blocking medication, which you'll take daily (as a pill) or receive as injections every 3 months for 6 months. You'll have a special imaging scan called a PSMA PET/CT at the beginning and again after 6 months to measure how well the medication is working. After completing the medication, you'll undergo surgery to remove your prostate. The entire process takes about 6 months from start to finish.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
United States