Plain-English translation of NCT07504471 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Pancreatic Neoplasms research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new approach to treat pancreatic cancer that has spread to the liver. The treatment combines sodium bicarbonate (to change the tumor environment), a chemotherapy regimen called NASOX, and a type of immune-boosting medication called a PD-1 inhibitor—all delivered directly into the blood vessels feeding the tumors. You would also take an oral chemotherapy pill called S-1 to help maintain the treatment's effect.
Pancreatic cancer that spreads to the liver is very difficult to treat and is a major reason why patients with this disease progress quickly. This trial exists to see whether delivering high concentrations of this medication directly to the tumors—instead of throughout the whole body—can work better and help people live longer.
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As a participant, you would receive treatment in the hospital or clinic through a catheter (thin tube) placed in the blood vessel feeding your liver tumors. The treatment involves infusing the medication combination directly to your tumors, with the goal of attacking cancer cells while limiting side effects to your whole body. You would also take the oral chemotherapy pill S-1 at home, and attend regular visits for blood tests, scans, and check-ups to monitor how you are doing and assess whether the treatment is working.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
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