What the trial was testing
The trial enrolled 117 patients with alzheimer's disease. The study was sponsored by University of Kansas Medical Center and tracked outcomes across the full group of patients who matched the trial's eligibility profile.
Researchers followed patients through treatment and into recovery, tracking the outcomes that mattered most for the disease being studied.
What the results showed
Hippocampal blood flow rose only in APOE4 carriers who exercised.
Journal of Cerebral Blood Flow and Metabolism · 2021 · NCT02000583
These findings — that rise in hippocampal blood flow with exercise — only in hypertensive APOE4 carriers — were published in the Journal of Cerebral Blood Flow and Metabolism and represent the headline result of the study.
Researchers tracked outcomes across 117 patients enrolled in the trial. The result was consistent enough across the group that the team felt confident reporting it.
What this means for patients
For patients with alzheimer's disease, this result changes the calculus on what to ask their care team about. Whether it changes day-to-day care depends on factors like disease subtype, prior treatments, and where the patient is in their care journey.
What you can do now
Aerobic exercise is free and broadly recommended. APOE4 genetic testing is available through doctors and consumer services. The American Heart Association and Alzheimer's Association both recommend regular aerobic exercise for brain health. Ask your primary care doctor about a starter exercise plan, especially if you have high blood pressure.
Eligibility for the treatments mentioned above depends on specific test results and clinical history. Bring this summary, the trial name, and your most recent labs or pathology report to your next visit.
Open alzheimer's disease trials
Neuroimaging in Healthy Aging and Senile Dementia (HASD_IND)
To identify factors that signal the transition from asymptomatic (preclinical) to symptomatic Alzheimer disease (AD).
Establishment of the Chinese Preclinical Alzheimer's Disease Study With Multiple Neuroimaging
The goal of this observational study is to investigate neuroimage and biomarkers in the Alzheimer's continuum in Chinese population. We aimed to: * To reveal the progress of AD by multiple neuroimage and biomarkers; * To reveal the longitudinal change of biomarkers and cognition of AD in Chinese population; * To investigate the interaction of markers between body and brain; * To set up new markers by neuroimage.